GL1X · GenesisL1 explorer

MolNFT v1 · #169318 · protein

PDE6 chicken gaf domain

6X88 · Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit…: “PDE6 chicken gaf domain”. X-ray diffraction, 10 pockets (best druggability 0.71). MolNFT v1 #169318 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
6X88
Type
protein
Length
757 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha'
EC
3.1.4.35
UniProt
P52731
Pockets
10 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 22% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ACone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35)protein38241% helix, 23% strandP52731
BCone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35)protein37540% helix, 22% strandP52731

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
13440.710.8343empty
22910.700.8433empty
31400.690.8932empty
41330.660.8833empty
51890.580.8125empty

Interfaces

1 interface between chains.

  • A–B · 2754 Ų buried · 27 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 6X88 · PDE6 chicken GAF domain · the same entry in another collection · chain A against A, TM-score 1.00
  • P52731 · AlphaFold monomer V2.0 prediction for cone cgmp-specific 3',5'-cyclic phosphodiesterase… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.