MolNFT v1 · #169112 · protein
Outward-facing state of the glutamate transporter homologue gltph in complex with tboa
6X17: “Outward-facing state of the glutamate transporter homologue gltph in complex with tboa”. Electron microscopy, 1 ligand (6OU), 13 pockets (best druggability 0.88). MolNFT v1 #169112 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6X17
- Type
- protein
- Length
- 1,245 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate transporter homologue gltph
- Ligands
- 6OU
- Pockets
- 13 · best druggability 0.88
Structure
electron microscopy · 1 distinct chain · 75% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Glutamate transporter homologue gltph | protein | 415 | 75% helix, 0% strand | — |
Ligands and binding sites
- 6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 677 | 0.88 | 0.91 | 42 | empty |
| 2 | 409 | 0.60 | 0.76 | 49 | empty |
| 3 | 370 | 0.60 | 0.77 | 46 | empty |
| 4 | 380 | 0.60 | 0.76 | 41 | empty |
| 5 | 431 | 0.59 | 0.74 | 38 | 6OU |
Interfaces
3 interfaces between chains.
- B–C · 1121 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 1106 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 1099 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 6X17 · Outward-facing state of the glutamate transporter homologue GltPh in complex with TBOA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6X17 · PDBe 6X17
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.