MolNFT v1 · #169107 · protein

Inward-facing apo-open state of the glutamate transporter homologue gltph

6X12: “Inward-facing apo-open state of the glutamate transporter homologue gltph”. Electron microscopy, 1 ligand (6OU), 5 pockets (best druggability 0.67). MolNFT v1 #169107 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6X12
Type: protein
Length: 407 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate transporter homologue gltph
Ligands: 6OU
Pockets: 5 · best druggability 0.67

Structure

electron microscopy · 1 distinct chain · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate transporter homologue gltph	protein	407	76% helix, 0% strand	—

Ligands and binding sites

6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	210	0.67	0.85	34	empty
2	282	0.55	0.76	30	empty
3	252	0.54	0.76	30	empty
4	73	0.34	0.75	14	empty
5	77	0.33	0.74	19	empty

Compared structures

6X12 · Inward-facing Apo-open state of the glutamate transporter homologue GltPh · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6X12 · PDBe 6X12

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