MolNFT v1 · #168919 · protein
Human vkor with phenindione
6WV6 · Vitamin K epoxide reductase, termini restrained by green…: “Human vkor with phenindione”. X-ray diffraction, 2 ligands (CRO, UAS), 2 pockets (best druggability 0.81). MolNFT v1 #168919 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6WV6
- Type
- protein
- Length
- 381 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vitamin K epoxide reductase, termini restrained by green fluorescent protein
- EC
- 1.17.4.4
- UniProt
- A0A059PIQ0, Q9BQB6
- Ligands
- CRO, UAS
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vitamin K epoxide reductase, termini restrained by green fluorescent protein (EC 1.17.4.4) | protein | 381 | 33% helix, 33% strand | A0A059PIQ0, Q9BQB6 |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
- UAS · Phenindione · ligand · chains A
- OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 658 | 0.81 | 0.85 | 72 | CRO |
| 2 | 249 | 0.76 | 0.89 | 34 | OLC, UAS |
Modifications
Observed in the structure: 2 cofactor, 2 disulfide (chromophore, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A059PIQ0
- Every structure of UniProt Q9BQB6
- Elsewhere: RCSB PDB 6WV6 · PDBe 6WV6 · UniProt A0A059PIQ0 · UniProt Q9BQB6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.