MolNFT v1 · #168788 · protein
Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery
6WR4 · Autophagy-related protein 9A: “Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery”. Electron microscopy, 1 ligand (LMN), 20 pockets (best druggability 0.74). MolNFT v1 #168788 on GenesisL1: 3D…
- PDB
- 6WR4
- Type
- protein
- Length
- 1,410 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Autophagy-related protein 9A
- UniProt
- Q7Z3C6
- Ligands
- LMN
- Pockets
- 20 · best druggability 0.74
Structure
electron microscopy · 1 distinct chain · 60% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Autophagy-related protein 9A | protein | 470 | 60% helix, 4% strand | Q7Z3C6 |
Ligands and binding sites
- LMN · Lauryl Maltose Neopentyl Glycol · ligand · 6 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 991 | 0.74 | 0.77 | 72 | empty |
| 2 | 479 | 0.70 | 0.80 | 36 | empty |
| 3 | 460 | 0.69 | 0.80 | 36 | empty |
| 4 | 433 | 0.69 | 0.80 | 37 | empty |
| 5 | 315 | 0.67 | 0.81 | 40 | LMN |
Interfaces
3 interfaces between chains.
- B–C · 1860 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1853 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1849 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6WR4 · Structure of human ATG9A, the only transmembrane protein of the core autophagy machinery · the same entry in another collection · chain A against A, TM-score 1.00
- Q7Z3C6 · AlphaFold monomer V2.0 prediction for autophagy-related protein 9A (Q7Z3C6) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z3C6
- Elsewhere: RCSB PDB 6WR4 · PDBe 6WR4 · UniProt Q7Z3C6
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