MolNFT v1 · #168701 · protein
Crystal structure of estrogen receptor alpha in complex with receptor degrader 6
6WOK: “Crystal structure of estrogen receptor alpha in complex with receptor degrader 6”. X-ray diffraction, 2 ligands (G9J, U6D). MolNFT v1 #168701 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WOK
- Type
- protein
- Length
- 919 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03372
- Ligands
- G9J, U6D
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | — | protein | 231 | — | P03372 |
| A | — | protein | 225 | — | P03372 |
| C | — | protein | 233 | — | P03372 |
| B | — | protein | 230 | — | P03372 |
Ligands and binding sites
- G9J · (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol · ligand · 3 copies · chains D, A, C
- U6D · (1R,3R)-1-(2,6-difluoro-4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline · ligand · 3 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6WOK · Crystal structure of estrogen receptor alpha in complex with receptor degrader 6 · the same entry in another collection · chain B against B, TM-score 1.00
- P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03372
- Elsewhere: RCSB PDB 6WOK · PDBe 6WOK · UniProt P03372
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