MolNFT v1 · #168423 · protein

Crystal structure of tetracycline destructase TET(X7)

6WG9: “Crystal structure of tetracycline destructase TET(X7)”. X-ray diffraction, 1 ligand (FAD), 8 pockets (best druggability 0.79). MolNFT v1 #168423 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6WG9
Type: protein
Length: 732 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tetracycline destructase TET(X7)
Ligands: FAD
Pockets: 8 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tetracycline destructase TET(X7)	protein	365	33% helix, 26% strand	—
B	Tetracycline destructase TET(X7)	protein	367	33% helix, 25% strand	—

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	949	0.79	0.81	73	FAD
2	1105	0.79	0.80	85	FAD
3	322	0.67	0.82	35	empty
4	108	0.49	0.81	17	empty
5	53	0.32	0.78	15	empty

Interfaces

1 interface between chains.

A–B · 733 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6WG9 · Crystal structure of tetracycline destructase Tet(X7) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6WG9 · PDBe 6WG9

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