MolNFT v1 · #168383 · protein
Il-22 signaling complex with il-22R1 and il-10RBETA
6WEO · Interleukin-10 receptor subunit beta: “Il-22 signaling complex with il-22R1 and il-10RBETA”. X-ray diffraction, 3 ligands (NAG, FUC, BMA), 20 pockets (best druggability 0.79). MolNFT v1 #168383 on GenesisL1: 3D structure, binding…
- PDB
- 6WEO
- Type
- protein
- Length
- 6,434 residues
- Chains
- 36
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-10 receptor subunit beta; Interleukin-22 receptor subunit alpha-1…
- UniProt
- Q61190, Q80XZ4, Q9JJY9
- Ligands
- NAG, FUC, BMA
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 9 distinct chains · 20% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 0 | Interleukin-10 receptor subunit beta | protein | 193 | 4% helix, 52% strand | Q61190 |
| 1, 4, 7, A, B, F, I, M, P, S, V, Y | Interleukin-22 receptor subunit alpha-1 | protein | 201 | 5% helix, 53% strand | Q80XZ4 |
| 2, 8, J, N | Interleukin-22 | protein | 140 | 66% helix, 0% strand | Q9JJY9 |
| 3, 6, C, E, H, K, R, U | Interleukin-10 receptor subunit beta | protein | 195 | 4% helix, 50% strand | Q61190 |
| 5, D, G, L, W, Z | Interleukin-22 | protein | 141 | 68% helix, 0% strand | Q9JJY9 |
| 9 | Interleukin-10 receptor subunit beta | protein | 186 | 4% helix, 47% strand | Q61190 |
| O | Interleukin-10 receptor subunit beta | protein | 196 | 4% helix, 51% strand | Q61190 |
| Q, T | Interleukin-22 | protein | 142 | 63% helix, 0% strand | Q9JJY9 |
| X | Interleukin-10 receptor subunit beta | protein | 197 | 4% helix, 50% strand | Q61190 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 38 copies · chains 1, C, 2, 4, E, 5, 6, 7, X, 9, 8, A, B, D, F, G, H, I, K, J, L, M, U, O, N, P, Q, R, S, T, V, W, Y, 0, Z
- FUC · alpha-L-fucopyranose · sugar · 24 copies · chains 1, 4, 6, 7, 8, D, E, F, H, I, K, C, M, O, P, R, S, U, V, X, 0, Y, Z
- BMA · beta-D-mannopyranose · sugar · 6 copies
- GOL · Glycerol · additive · 7 copies · chains A, H, Y, J, K, M, N, O
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1152 | 0.79 | 0.81 | 119 | empty |
| 2 | 781 | 0.77 | 0.81 | 80 | empty |
| 3 | 1049 | 0.75 | 0.78 | 90 | GOL |
| 4 | 796 | 0.75 | 0.79 | 71 | empty |
| 5 | 880 | 0.74 | 0.78 | 80 | FUC |
Interfaces
73 interfaces between chains.
- F–M · 1128 Ų buried · 13 hydrogen bonds · protein-protein
- 7–B · 1089 Ų buried · 10 hydrogen bonds · protein-protein
- A–Y · 1074 Ų buried · 6 hydrogen bonds · protein-protein
- Y–Z · 950 Ų buried · 12 hydrogen bonds · protein-protein
- S–T · 924 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 72 disulfide, 24 glycan (disulfide, N-glycosylation).
Compared structures
- 6WEO · IL-22 Signaling Complex with IL-22R1 and IL-10Rbeta · the same entry in another collection · chain 9 against 9, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61190
- Every structure of UniProt Q80XZ4
- Every structure of UniProt Q9JJY9
- Elsewhere: RCSB PDB 6WEO · PDBe 6WEO · UniProt Q61190 · UniProt Q80XZ4 · UniProt Q9JJY9
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