MolNFT v1 · #168293 · protein
Crystal structure of MRECK(CC4) in fusion with engineered mbp at medium resolution
6WBH · Maltodextrin-binding PROTEIN,REVERSION-inducing cysteine…: “Crystal structure of MRECK(CC4) in fusion with engineered mbp at medium resolution”. X-ray diffraction, 3 ligands (GLC, ZN, CL), 2 pockets (best druggability 0.71). MolNFT…
- PDB
- 6WBH
- Type
- protein
- Length
- 431 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maltodextrin-binding PROTEIN,REVERSION-inducing cysteine- rich protein with kazal motifs…
- UniProt
- A0A376KDN7, Q9Z0J1
- Ligands
- GLC, ZN, CL
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maltodextrin-binding PROTEIN,REVERSION-inducing cysteine- rich protein with kazal motifs fusion | protein | 431 | 49% helix, 18% strand | A0A376KDN7, Q9Z0J1 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- ZN · Zinc ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 338 | 0.71 | 0.84 | 35 | GLC |
| 2 | 623 | 0.66 | 0.76 | 67 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6WBH · Crystal structure of mRECK(CC4) in fusion with engineered MBP at medium resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Z0J1 · AlphaFold monomer V2.0 prediction for reversion-inducing cysteine- rich protein with… · a predicted model of the same protein · chain A against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A376KDN7
- Every structure of UniProt Q9Z0J1
- Elsewhere: RCSB PDB 6WBH · PDBe 6WBH · UniProt A0A376KDN7 · UniProt Q9Z0J1
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