MolNFT v1 · #168287 · protein
Structure of mouse importin alpha - MLH1-E475A nls peptide complex
6WBB · Importin subunit alpha-1: “Structure of mouse importin alpha - MLH1-E475A nls peptide complex”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #168287 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WBB
- Type
- protein
- Length
- 444 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; DNA mismatch repair protein MLH1
- UniProt
- P52293, P40692
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I | Importin subunit alpha-1 | protein | 426 | 73% helix, 0% strand | P52293 |
| C | DNA mismatch repair protein MLH1 | protein | 8 | 0% helix, 0% strand | P40692 |
| B | DNA mismatch repair protein MLH1 | protein | 10 | 0% helix, 0% strand | P40692 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.46 | 0.82 | 13 | empty |
Interfaces
2 interfaces between chains.
- I–B · 813 Ų buried · 19 hydrogen bonds · protein-protein
- I–C · 635 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 6WBB · Structure of Mouse Importin alpha - MLH1-E475A NLS peptide complex · the same entry in another collection · chain I against I, TM-score 1.00
- P40692 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MLH1 (P40692) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P40692
- Elsewhere: RCSB PDB 6WBB · PDBe 6WBB · UniProt P52293 · UniProt P40692
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