MolNFT v1 · #168286 · protein
Structure of mouse importin alpha MLH1- R470A nls peptide complex
6WBA · Importin subunit alpha-1: “Structure of mouse importin alpha MLH1- R470A nls peptide complex”. X-ray diffraction, 1 pocket (best druggability 0.47). MolNFT v1 #168286 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WBA
- Type
- protein
- Length
- 445 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; DNA mismatch repair protein MLH1
- UniProt
- P52293, P40692
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 426 | 74% helix, 0% strand | P52293 |
| C | DNA mismatch repair protein MLH1 | protein | 9 | 0% helix, 0% strand | P40692 |
| B | DNA mismatch repair protein MLH1 | protein | 10 | 0% helix, 0% strand | P40692 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.47 | 0.82 | 13 | empty |
Interfaces
2 interfaces between chains.
- A–B · 746 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 607 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 6WBA · Structure of Mouse Importin alpha MLH1- R470A NLS Peptide Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P40692 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MLH1 (P40692) · a predicted model of the same protein · chain B against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt P40692
- Elsewhere: RCSB PDB 6WBA · PDBe 6WBA · UniProt P52293 · UniProt P40692
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