MolNFT v1 · #168263 · protein
A crystal structure of EGFR(T790M/V948R) in complex with LN3754
6WAK: “A crystal structure of EGFR(T790M/V948R) in complex with LN3754”. X-ray diffraction, 3 ligands (ANP, TQA, MG). MolNFT v1 #168263 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6WAK
- Type
- protein
- Length
- 1,209 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P00533
- Ligands
- ANP, TQA, MG
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | — | protein | 297 | — | P00533 |
| A | — | protein | 297 | — | P00533 |
| B | — | protein | 316 | — | P00533 |
| C | — | protein | 299 | — | P00533 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 3 copies · chains D, A, B
- TQA · N-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1H-imidazol-4-yl}phenyl)-2-[(1-oxo-1, 3-dihydro-2H-isoindol-2-yl)methyl]benzamide · ligand · chains C
- MG · Magnesium ion · metal · 3 copies · chains D, A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6WAK · A crystal structure of EGFR(T790M/V948R) in complex with LN3754 · the same entry in another collection · chain C against C, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain C against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 6WAK · PDBe 6WAK · UniProt P00533
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.