MolNFT v1 · #168130 · protein
Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation
6W6C · Probable dimethyladenosine transferase: “Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation”. X-ray diffraction, 6 pockets (best druggability 0.66). MolNFT v1 #168130 on…
- PDB
- 6W6C
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable dimethyladenosine transferase
- EC
- 2.1.1.183
- UniProt
- Q9UNQ2
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable dimethyladenosine transferase (EC 2.1.1.183) | protein | 278 | 45% helix, 18% strand | Q9UNQ2 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.66 | 0.86 | 37 | empty |
| 2 | 191 | 0.59 | 0.81 | 27 | empty |
| 3 | 257 | 0.56 | 0.77 | 26 | empty |
| 4 | 115 | 0.38 | 0.74 | 15 | empty |
| 5 | 67 | 0.38 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1189 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6W6C · Structural and catalytic roles of human 18S rRNA methyltransferases DIMT1 in ribosome… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UNQ2 · AlphaFold monomer V2.0 prediction for probable dimethyladenosine transferase (Q9UNQ2) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UNQ2
- Elsewhere: RCSB PDB 6W6C · PDBe 6W6C · UniProt Q9UNQ2
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