MolNFT v1 · #167951 · protein
Amyloid-BETA(1-40) fibril derived from ALZHEIMER'S disease cortical tissue
6W0O · Amyloid-beta precursor protein: “Amyloid-BETA(1-40) fibril derived from ALZHEIMER'S disease cortical tissue”. Electron microscopy; solid-state nmr, 1 pocket (best druggability 0.50). MolNFT v1 #167951 on GenesisL1: 3D structure…
- PDB
- 6W0O
- Type
- protein
- Length
- 186 residues
- Chains
- 6
- Method
- electron microscopy; solid-state nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amyloid-beta precursor protein
- UniProt
- P05067
- Pockets
- 1 · best druggability 0.50
Structure
electron microscopy; solid-state nmr · 1 distinct chain · 0% helix, 61% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1, 2, 3, 4, 5, 6 | Amyloid-beta precursor protein | protein | 31 | 0% helix, 61% strand | P05067 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.50 | 0.80 | 24 | empty |
Interfaces
9 interfaces between chains.
- 4–5 · 1260 Ų buried · 35 hydrogen bonds · protein-protein
- 5–6 · 1257 Ų buried · 35 hydrogen bonds · protein-protein
- 2–3 · 1249 Ų buried · 38 hydrogen bonds · protein-protein
- 1–2 · 1246 Ų buried · 38 hydrogen bonds · protein-protein
- 2–5 · 438 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6W0O · Amyloid-beta(1-40) fibril derived from Alzheimer's disease cortical tissue · the same entry in another collection · chain 6 against 6, TM-score 1.00
- P05067 · AlphaFold monomer V2.0 prediction for amyloid-beta precursor protein (P05067) · a predicted model of the same protein · chain 1 against A, TM-score 0.33
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05067
- Elsewhere: RCSB PDB 6W0O · PDBe 6W0O · UniProt P05067
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