MolNFT v1 · #167870 · protein

Sthk P300A cyclic nucleotide-gated potassium channel in a putative active state, in complex with camp

6VY0: “Sthk P300A cyclic nucleotide-gated potassium channel in a putative active state, in complex with camp”. Electron microscopy, 18 pockets (best druggability 0.73). MolNFT v1 #167870 on GenesisL1: 3D structure, binding sites and…

PDB: 6VY0
Type: protein
Length: 1,540 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sthk
UniProt: G0GA88
Pockets: 18 · best druggability 0.73

Structure

electron microscopy · 1 distinct chain · 61% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Sthk	protein	385	61% helix, 8% strand	G0GA88

Pockets

18 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	613	0.73	0.80	84	empty
2	769	0.72	0.78	88	empty
3	968	0.71	0.75	100	empty
4	916	0.69	0.75	93	empty
5	505	0.66	0.78	53	empty

Interfaces

6 interfaces between chains.

C–D · 481 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 340 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 340 Å² buried · 0 hydrogen bonds · protein-protein
A–B · 307 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 47 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6VY0 · SthK P300A cyclic nucleotide-gated potassium channel in a putative active state, in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G0GA88
Elsewhere: RCSB PDB 6VY0 · PDBe 6VY0 · UniProt G0GA88

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