MolNFT v1 · #167846 · protein
Bestrophin-2 CA2+- unbound state 2 (egta only)
6VX8: “Bestrophin-2 CA2+- unbound state 2 (egta only)”. Electron microscopy, 1 ligand (CL), 20 pockets (best druggability 0.81). MolNFT v1 #167846 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VX8
- Type
- protein
- Length
- 1,620 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bestrophin
- UniProt
- E1BF86
- Ligands
- CL
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, A, B, C, D | Bestrophin | protein | 324 | 69% helix, 1% strand | E1BF86 |
Ligands and binding sites
- CL · Chloride ion · ion · chains E, A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 977 | 0.81 | 0.82 | 85 | empty |
| 2 | 83 | 0.73 | 0.96 | 18 | empty |
| 3 | 67 | 0.72 | 0.97 | 17 | empty |
| 4 | 70 | 0.72 | 0.97 | 17 | empty |
| 5 | 67 | 0.71 | 0.96 | 17 | empty |
Interfaces
10 interfaces between chains.
- E–A · 3859 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 3848 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 3847 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 3844 Ų buried · 20 hydrogen bonds · protein-protein
- E–D · 3797 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6VX8 · bestrophin-2 Ca2+- unbound state 2 (EGTA only) · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E1BF86
- Elsewhere: RCSB PDB 6VX8 · PDBe 6VX8 · UniProt E1BF86
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