MolNFT v1 · #167824 · protein
Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II
6VWJ · Leucine-zippered human type 1 insulin-like growth factor…: “Leg region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in…”. Electron microscopy, 11 pockets (best druggability 0.77).…
- PDB
- 6VWJ
- Type
- protein
- Length
- 747 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain
- EC
- 2.7.10.1
- UniProt
- P08069, P03069
- Pockets
- 11 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 9% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (EC 2.7.10.1) | protein | 240 | 12% helix, 43% strand | P08069, P03069 |
| B | Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain (EC 2.7.10.1) | protein | 507 | 8% helix, 36% strand | P08069, P03069 |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1109 | 0.77 | 0.79 | 97 | empty |
| 2 | 88 | 0.77 | 0.97 | 26 | empty |
| 3 | 442 | 0.65 | 0.78 | 52 | empty |
| 4 | 162 | 0.53 | 0.79 | 26 | empty |
| 5 | 127 | 0.38 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1476 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 17 disulfide (disulfide).
Compared structures
- 6VWJ · Leg region of the closed conformation of the human type 1 insulin-like growth factor… · the same entry in another collection · chain A against A, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain A against A, TM-score 0.17
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Every structure of UniProt P03069
- Elsewhere: RCSB PDB 6VWJ · PDBe 6VWJ · UniProt P08069 · UniProt P03069
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