MolNFT v1 · #167707 · protein
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of rorgt
6VSW: “Optimization and biological evaluation of thiazole-bis-amide inverse agonists of rorgt”. X-ray diffraction, 1 ligand (RG7). MolNFT v1 #167707 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VSW
- Type
- protein
- Length
- 453 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q6I9R9
- Ligands
- RG7
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 228 | — | Q6I9R9 |
| B | — | protein | 225 | — | Q6I9R9 |
Ligands and binding sites
- RG7 · 5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VSW · Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORgt · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6I9R9
- Elsewhere: RCSB PDB 6VSW · PDBe 6VSW · UniProt Q6I9R9
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