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Ligand · RG7

RG7 · 5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide

RG7, 5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide (C23 H26 Cl2 F4 N4 O5 S2, 649.5 g/mol), in the MolNFT structures on…

Component
RG7
Formula
C23 H26 Cl2 F4 N4 O5 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

RG7 in 2 structures; the first of them:

  • 6VSW · Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORgt · RG7 A501 · binds GLN286, LEU287, TRP317, CYS320, HIS323, LEU324, ALA327, MET358 and 15 more
  • 6VSW · Optimization and biological evaluation of thiazole-bis-amide inverse agonists of rorgt · RG7 A501 · binds GLN286, LEU287, TRP317, CYS320, HIS323, LEU324, ALA327, VAL361 and 10 more

Residues it binds most

LEU 4, PHE 4, HIS 4, ILE 4, MET 4, VAL 4, ALA 4, CYS 4, GLN 4, TRP 4 (residue and the binding sites it lines).

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