MolNFT v1 · #167321 · protein
Doublet tau fibril from corticobasal degeneration human brain tissue
6VH7 · Microtubule-associated protein tau: “Doublet tau fibril from corticobasal degeneration human brain tissue”. Electron microscopy, 11 pockets (best druggability 0.52). MolNFT v1 #167321 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6VH7
- Type
- protein
- Length
- 642 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 11 · best druggability 0.52
Structure
electron microscopy · 1 distinct chain · 0% helix, 75% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, E, F, G | Microtubule-associated protein tau | protein | 107 | 0% helix, 75% strand | P10636 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.52 | 0.77 | 31 | empty |
| 2 | 232 | 0.51 | 0.76 | 33 | empty |
| 3 | 62 | 0.47 | 0.84 | 20 | empty |
| 4 | 89 | 0.46 | 0.81 | 21 | empty |
| 5 | 146 | 0.45 | 0.76 | 20 | empty |
Interfaces
13 interfaces between chains.
- E–F · 4447 Ų buried · 165 hydrogen bonds · protein-protein
- F–G · 4441 Ų buried · 162 hydrogen bonds · protein-protein
- A–B · 4437 Ų buried · 165 hydrogen bonds · protein-protein
- B–C · 4432 Ų buried · 162 hydrogen bonds · protein-protein
- C–G · 141 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6VH7 · Doublet Tau Fibril from Corticobasal Degeneration Human Brain Tissue · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 6VH7 · PDBe 6VH7 · UniProt P10636
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.