MolNFT v1 · #167298 · protein
Estrogen receptor alpha ligand binding domain Y537S mutant in complex with lasofoxifene
6VGH: “Estrogen receptor alpha ligand binding domain Y537S mutant in complex with lasofoxifene”. X-ray diffraction, 1 ligand (C3D). MolNFT v1 #167298 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VGH
- Type
- protein
- Length
- 456 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03372
- Ligands
- C3D
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 229 | — | P03372 |
| B | — | protein | 227 | — | P03372 |
Ligands and binding sites
- C3D · (5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6VGH · Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant In Complex with Lasofoxifene · the same entry in another collection · chain A against A, TM-score 1.00
- P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03372
- Elsewhere: RCSB PDB 6VGH · PDBe 6VGH · UniProt P03372
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