MolNFT v1 · #167284 · protein
Structure of unliganded, inactive PTK7 kinase domain
6VG3 · Inactive tyrosine-protein kinase 7: “Structure of unliganded, inactive PTK7 kinase domain”. X-ray diffraction, 6 pockets (best druggability 0.78). MolNFT v1 #167284 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6VG3
- Type
- protein
- Length
- 821 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inactive tyrosine-protein kinase 7
- UniProt
- Q13308
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inactive tyrosine-protein kinase 7 | protein | 277 | 40% helix, 19% strand | Q13308 |
| B | Inactive tyrosine-protein kinase 7 | protein | 279 | 40% helix, 18% strand | Q13308 |
| C | Inactive tyrosine-protein kinase 7 | protein | 265 | 41% helix, 20% strand | Q13308 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1190 | 0.78 | 0.80 | 118 | empty |
| 2 | 334 | 0.69 | 0.83 | 37 | empty |
| 3 | 262 | 0.68 | 0.84 | 31 | empty |
| 4 | 300 | 0.68 | 0.83 | 31 | empty |
| 5 | 164 | 0.49 | 0.78 | 25 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1232 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 442 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13308
- Elsewhere: RCSB PDB 6VG3 · PDBe 6VG3 · UniProt Q13308
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