MolNFT v1 · #319456 · protein
AlphaFold monomer V2.0 prediction for inactive tyrosine-protein kinase 7 (Q13308)
Q13308: “AlphaFold monomer V2.0 prediction for inactive tyrosine-protein kinase 7 (Q13308)”. 7 pockets (best druggability 0.65). MolNFT v1 #319456 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q13308
- Type
- protein
- Length
- 1,070 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5f160919213e42170f231D5fbA6c94153Bbc852c
- Molecule
- Inactive tyrosine-protein kinase 7
- UniProt
- Q13308
- Pockets
- 7 · best druggability 0.65
Structure
1 distinct chain · 15% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inactive tyrosine-protein kinase 7 | protein | 1070 | 15% helix, 37% strand | Q13308 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.65 | 0.81 | 31 | empty |
| 2 | 332 | 0.59 | 0.77 | 28 | empty |
| 3 | 146 | 0.56 | 0.82 | 21 | empty |
| 4 | 237 | 0.47 | 0.73 | 27 | empty |
| 5 | 61 | 0.33 | 0.77 | 12 | empty |
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 6VG3 · Structure of unliganded, inactive PTK7 kinase domain · an experimental structure of the same protein · chain A against B, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13308
- Elsewhere: UniProt Q13308 · AlphaFold DB Q13308
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