MolNFT v1 · #167244 · protein

Human insulin analog: [GLUB10,HISA8,ARGA9,TYRB20]-doi

6VET · Insulin a chain: “Human insulin analog: [GLUB10,HISA8,ARGA9,TYRB20]-doi”. X-ray diffraction, 2 pockets (best druggability 0.59). MolNFT v1 #167244 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6VET
Type: protein
Length: 126 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin a chain; Insulin B chain
UniProt: P01308
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E	Insulin a chain	protein	20	60% helix, 0% strand	P01308
B, D, F	Insulin B chain	protein	22	45% helix, 0% strand	P01308

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	222	0.59	0.79	26	empty
2	55	0.28	0.74	19	empty

Interfaces

9 interfaces between chains.

E–F · 532 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 527 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 509 Å² buried · 5 hydrogen bonds · protein-protein
D–F · 379 Å² buried · 1 hydrogen bond · protein-protein
B–D · 374 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 9 disulfide (disulfide).

Compared structures

6VET · Human insulin analog: [GluB10,HisA8,ArgA9,TyrB20]-DOI · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01308
Elsewhere: RCSB PDB 6VET · PDBe 6VET · UniProt P01308

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