MolNFT v1 · #167096 · protein
Cryo-EM structure of an undecameric chicken CALHM1 and human CALHM2 chimera
6VAL · Green fluorescent protein, CALHM1,CALMH2 chimera: “Cryo-EM structure of an undecameric chicken CALHM1 and human CALHM2 chimera”. Electron microscopy, 20 pockets (best druggability 0.71). MolNFT v1 #167096 on GenesisL1: 3D structure…
- PDB
- 6VAL
- Type
- protein
- Length
- 2,827 residues
- Chains
- 11
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Green fluorescent protein, CALHM1,CALMH2 chimera
- UniProt
- P42212, A0A1D5NWS1, Q9HA72
- Pockets
- 20 · best druggability 0.71
Structure
electron microscopy · 1 distinct chain · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K | Green fluorescent protein, CALHM1,CALMH2 chimera | protein | 257 | 67% helix, 0% strand | P42212, A0A1D5NWS1, Q9HA72 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 532 | 0.71 | 0.80 | 78 | empty |
| 2 | 536 | 0.71 | 0.80 | 83 | empty |
| 3 | 499 | 0.70 | 0.80 | 76 | empty |
| 4 | 480 | 0.70 | 0.80 | 71 | empty |
| 5 | 411 | 0.69 | 0.81 | 66 | empty |
Interfaces
22 interfaces between chains.
- A–K · 2771 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2769 Ų buried · 21 hydrogen bonds · protein-protein
- I–J · 2768 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 2767 Ų buried · 20 hydrogen bonds · protein-protein
- J–K · 2765 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 6VAL · Cryo-EM structure of an undecameric chicken CALHM1 and human CALHM2 chimera · the same entry in another collection · chain K against K, TM-score 1.00
- Q9HA72 · AlphaFold monomer V2.0 prediction for calcium homeostasis modulator protein 2 (Q9HA72) · a predicted model of the same protein · chain E against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42212
- Every structure of UniProt A0A1D5NWS1
- Every structure of UniProt Q9HA72
- Elsewhere: RCSB PDB 6VAL · PDBe 6VAL · UniProt P42212 · UniProt A0A1D5NWS1 · UniProt Q9HA72
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