UniProt Q9HA72
Calcium homeostasis modulator protein 2 (Q9HA72)
Calcium homeostasis modulator protein 2 (UniProt Q9HA72): 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q9HA72
- Protein
- Calcium homeostasis modulator protein 2
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 35 · 2 records with a druggable one
Structures
14 records of Q9HA72 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LMU | Cryo-EM structure of the human CALHM2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | — | — |
| 6LMU | Cryo-EM structure of the human CALHM2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | — | — |
| 6LMW | Cryo-EM structure of the calhm chimeric construct (8-mer) | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 6LMX | Cryo-EM structure of the calhm chimeric construct (9-mer) | electron microscopy | A, B, C, D, E, F, G, H, I | — | — |
| 6UIV | Cryo-EM structure of human CALHM2 in an ACTIVE/OPEN state | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | — | — |
| 6UIW | Cryo-EM structure of human CALHM2 in a ruthenium red-bound inhibited state | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | R2R | 20 (best 0.74) |
| 6UIW | Cryo-EM structure of human CALHM2 in a ruthenium red-bound inhibited state | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | R2R | — |
| 6UIX | Cryo-EM structure of human CALHM2 gap junction | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | — |
| 6VAI | Cryo-EM structure of a dimer of undecameric human CALHM2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V | — | — |
| 6VAK | Cryo-EM structure of human CALHM2 | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | — | — |
| 6VAL | Cryo-EM structure of an undecameric chicken CALHM1 and human CALHM2 chimera | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | — | — |
| 6VAL | Cryo-EM structure of an undecameric chicken CALHM1 and human CALHM2 chimera | electron microscopy | A, B, C, D, E, F, G, H, I, J, K | — | — |
| 8RMM | Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4 | electron microscopy | C, D, E, F, G, H, I, J | PLC | 15 (best 0.80) |
| Q9HA72 | AlphaFold monomer V2.0 prediction for calcium homeostasis modulator protein 2 (Q9HA72) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8RMM chain C against the predicted model Q9HA72: TM-score 0.95, RMSD 1.54 Å
- 6UIV chain H against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain J against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain E against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain G against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain A against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain C against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain F against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain D against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
- 6UIV chain I against the predicted model Q9HA72: TM-score 0.95, RMSD 1.57 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.