MolNFT v1 · #167070 · protein
Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14C
6V9U: “Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14C”. X-ray diffraction, 4 ligands (QSM, NAG, MAN). MolNFT v1 #167070 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6V9U
- Type
- protein
- Length
- 1,473 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9NR97
- Ligands
- QSM, NAG, MAN, BMA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 738 | — | Q9NR97 |
| B | — | protein | 735 | — | Q9NR97 |
Ligands and binding sites
- QSM · 2-(3,4-dimethoxyphenyl)-5-(piperidin-4-yl)-3-(propan-2-yl)-1H-indole · ligand · 2 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 29 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 8 copies · chains B
- BMA · beta-D-mannopyranose · sugar · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6V9U · Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 14c · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NR97
- Elsewhere: RCSB PDB 6V9U · PDBe 6V9U · UniProt Q9NR97
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