MolNFT v1 · #167031 · protein

RSC CORE

6V8O · High temperature lethal protein 1: “RSC CORE”. Electron microscopy, 1 ligand (ZN), 20 pockets (best druggability 0.86). MolNFT v1 #167031 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6V8O
Type: protein
Length: 3,156 residues
Chains: 22
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: High temperature lethal protein 1; Chromatin structure-remodeling complex protein RSC14…
EC: 3.6.4.12
UniProt: Q9URQ5, P38210, P32832, Q06488, Q06639, Q02206, P43609, P25632, Q03124, Q07979, Q06168, P32597, P38781
Ligands: ZN
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 21 distinct chains · 47% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	High temperature lethal protein 1	protein	60	78% helix, 0% strand	Q9URQ5
D	Chromatin structure-remodeling complex protein RSC14	protein	100	50% helix, 0% strand	P38210
E	Chromatin structure-remodeling complex subunit RSC7	protein	120	43% helix, 18% strand	P32832
F	Chromatin structure-remodeling complex subunit RSC2	protein	67	19% helix, 4% strand	Q06488
G	Chromatin structure-remodeling complex protein RSC3	protein	53	42% helix, 9% strand	Q06639
H	Chromatin structure-remodeling complex subunit RSC4	protein	131	6% helix, 46% strand	Q02206
I	Chromatin structure-remodeling complex protein RSC8	protein	293	40% helix, 13% strand	P43609
J	Chromatin structure-remodeling complex protein RSC8	protein	115	84% helix, 0% strand	P43609
K	Chromatin structure-remodeling complex protein RSC8	protein	109	75% helix, 9% strand	P43609
L	Chromatin structure-remodeling complex protein RSC8	protein	298	39% helix, 9% strand	P43609
M	Chromatin structure-remodeling complex protein RSC6	protein	310	44% helix, 10% strand	P25632
N	Chromatin structure-remodeling complex subunit RSC9	protein	412	60% helix, 1% strand	Q03124
O	Chromatin structure-remodeling complex protein RSC58	protein	384	42% helix, 9% strand	Q07979
Q	Chromatin structure-remodeling complex subunit SFH1	protein	264	34% helix, 18% strand	Q06168
R	Nuclear protein STH1/NPS1 (EC 3.6.4.12)	protein	262	60% helix, 2% strand	P32597
S	Chromatin structure-remodeling complex protein RSC30	protein	34	65% helix, 15% strand	P38781
2	Unknown protein	protein	28	0% helix, 4% strand	—
3, 4	Unknown protein	protein	19	89% helix, 0% strand	—
5	Unknown protein	protein	14	86% helix, 0% strand	—
6	Unknown protein	protein	15	87% helix, 0% strand	—
7	Unknown protein	protein	49	0% helix, 45% strand	—

Ligands and binding sites

ZN · Zinc ion · metal · chains I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	927	0.86	0.88	145	empty
2	1138	0.86	0.87	163	empty
3	452	0.84	0.91	51	empty
4	936	0.84	0.86	89	empty
5	725	0.83	0.86	73	empty

Interfaces

74 interfaces between chains.

O–R · 5098 Å² buried · 51 hydrogen bonds · protein-protein
L–O · 3126 Å² buried · 24 hydrogen bonds · protein-protein
I–Q · 2893 Å² buried · 24 hydrogen bonds · protein-protein
M–N · 2656 Å² buried · 16 hydrogen bonds · protein-protein
E–I · 2629 Å² buried · 45 hydrogen bonds · protein-protein

Compared structures

6V8O · RSC core · the same entry in another collection · chain I against I, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9URQ5
Every structure of UniProt P38210
Every structure of UniProt P32832
Every structure of UniProt Q06488
Every structure of UniProt Q06639
Every structure of UniProt Q02206
Every structure of UniProt P43609
Every structure of UniProt P25632
Every structure of UniProt Q03124
Every structure of UniProt Q07979
Every structure of UniProt Q06168
Every structure of UniProt P32597
Every structure of UniProt P38781
Elsewhere: RCSB PDB 6V8O · PDBe 6V8O · UniProt Q9URQ5 · UniProt P38210 · UniProt P32832 · UniProt Q06488 · UniProt Q06639 · UniProt Q02206 · UniProt P43609 · UniProt P25632 · UniProt Q03124 · UniProt Q07979 · UniProt Q06168 · UniProt P32597 · UniProt P38781

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.