MolNFT v1 · #16695 · protein

Importin beta bound to a glfg nucleoporin peptide

1O6P · Importin beta-1 subunit: “Importin beta bound to a glfg nucleoporin peptide”. X-ray diffraction, 9 pockets (best druggability 0.48). MolNFT v1 #16695 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1O6P
Type: protein
Length: 894 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin beta-1 subunit; Synthetic glfg peptide
UniProt: Q14974
Pockets: 9 · best druggability 0.48

Structure

x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Importin beta-1 subunit	protein	440	74% helix, 0% strand	Q14974
C, D	Synthetic glfg peptide	protein	4	0% helix, 0% strand	—
E, F	Synthetic glfg peptide	protein	3	0% helix, 0% strand	—

Pockets

9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.48	0.76	20	empty
2	168	0.45	0.75	21	empty
3	58	0.37	0.79	14	empty
4	53	0.36	0.78	10	empty
5	76	0.34	0.75	15	empty

Interfaces

4 interfaces between chains.

A–E · 268 Å² buried · 3 hydrogen bonds · protein-protein
B–F · 268 Å² buried · 3 hydrogen bonds · protein-protein
A–D · 180 Å² buried · 1 hydrogen bond · protein-protein
B–C · 180 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1O6P · Importin Beta bound to a GLFG Nucleoporin peptide · the same entry in another collection · chain C against C, TM-score 1.00
Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14974
Elsewhere: RCSB PDB 1O6P · PDBe 1O6P · UniProt Q14974

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