MolNFT v1 · #166941 · protein

Structure of gamma-tubulin in the native human gamma-tubulin ring complex

6V5V · Tubulin gamma-1 chain: “Structure of gamma-tubulin in the native human gamma-tubulin ring complex”. Electron microscopy, 1 ligand (GDP), 5 pockets (best druggability 0.43). MolNFT v1 #166941 on GenesisL1: 3D structure, binding sites…

PDB: 6V5V
Type: protein
Length: 369 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tubulin gamma-1 chain
UniProt: P23258
Ligands: GDP
Pockets: 5 · best druggability 0.43

Structure

electron microscopy · 1 distinct chain · 47% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
g	Tubulin gamma-1 chain	protein	369	47% helix, 15% strand	P23258

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains g

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.43	0.79	15	empty
2	70	0.40	0.79	20	GDP
3	92	0.39	0.77	16	empty
4	58	0.31	0.76	15	empty
5	60	0.28	0.74	15	empty

Compared structures

6V5V · Structure of gamma-tubulin in the native human gamma-tubulin ring complex · the same entry in another collection · chain g against g, TM-score 1.00
P23258 · AlphaFold monomer V2.0 prediction for tubulin gamma-1 chain (P23258) · a predicted model of the same protein · chain g against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23258
Elsewhere: RCSB PDB 6V5V · PDBe 6V5V · UniProt P23258

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