MolNFT v1 · #166938 · protein

EGFR(T790M/V948R) in complex with LN2084

6V5N: “EGFR(T790M/V948R) in complex with LN2084”. X-ray diffraction, 2 ligands (QP7, CL). MolNFT v1 #166938 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6V5N
Type: protein
Length: 1,213 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P00533
Ligands: QP7, CL

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
D	—	protein	308	—	P00533
A	—	protein	314	—	P00533
B	—	protein	297	—	P00533
C	—	protein	294	—	P00533

Ligands and binding sites

QP7 · 3-[4-(4-fluorophenyl)-5-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-imidazol-2-yl]propan-1-ol · ligand · 4 copies · chains D, A, B, C
CL · Chloride ion · ion · 4 copies · chains D, A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6V5N · EGFR(T790M/V948R) in complex with LN2084 · the same entry in another collection · chain C against C, TM-score 1.00
P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain C against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00533
Elsewhere: RCSB PDB 6V5N · PDBe 6V5N · UniProt P00533

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