MolNFT v1 · #166894 · protein
Structure of the rat vesicular glutamate transporter 2 determined by single particle cryo-EM
6V4D: “Structure of the rat vesicular glutamate transporter 2 determined by single particle cryo-EM”. Electron microscopy, 5 pockets (best druggability 0.77). MolNFT v1 #166894 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6V4D
- Type
- protein
- Length
- 422 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vesicular glutamate transporter 2
- UniProt
- Q9JI12
- Pockets
- 5 · best druggability 0.77
Structure
electron microscopy · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vesicular glutamate transporter 2 | protein | 422 | 71% helix, 0% strand | Q9JI12 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 649 | 0.77 | 0.82 | 70 | empty |
| 2 | 230 | 0.57 | 0.78 | 22 | empty |
| 3 | 166 | 0.47 | 0.76 | 26 | empty |
| 4 | 61 | 0.42 | 0.80 | 13 | empty |
| 5 | 84 | 0.34 | 0.74 | 24 | empty |
Compared structures
- Q9JI12 · AlphaFold monomer V2.0 prediction for vesicular glutamate transporter 2 (Q9JI12) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9JI12
- Elsewhere: RCSB PDB 6V4D · PDBe 6V4D · UniProt Q9JI12
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