MolNFT v1 · #166744 · protein

Crystal structure of the ternary complex of KRIT1 bound to both the RAP1 GTPase and HKI6

6UZK: “Crystal structure of the ternary complex of KRIT1 bound to both the RAP1 GTPase and HKI6”. X-ray diffraction, 3 ligands (QMA, GNP, MG). MolNFT v1 #166744 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6UZK
Type: protein
Length: 470 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O00522, P61224
Ligands: QMA, GNP, MG

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	307	—	O00522
B	—	protein	163	—	P61224

Ligands and binding sites

QMA · 2-hydroxy-6-methoxynaphthalene-1-carbaldehyde · ligand · chains A
GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains B
MG · Magnesium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6UZK · Crystal Structure of the Ternary Complex of KRIT1 bound to both the Rap1 GTPase and HKi6 · the same entry in another collection · chain A against A, TM-score 1.00
O00522 · AlphaFold monomer V2.0 prediction for krev interaction trapped protein 1 (O00522) · a predicted model of the same protein · chain A against A, TM-score 0.99
P61224 · AlphaFold monomer V2.0 prediction for RAS-related protein rap-1B (P61224) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00522
Every structure of UniProt P61224
Elsewhere: RCSB PDB 6UZK · PDBe 6UZK · UniProt O00522 · UniProt P61224

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