MolNFT v1 · #166704 · protein

Crystal structure of TEAD2 bound to compound 1

6UYB: “Crystal structure of TEAD2 bound to compound 1”. X-ray diffraction, 1 ligand (QSJ). MolNFT v1 #166704 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6UYB
Type: protein
Length: 402 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q15562
Ligands: QSJ

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	192	—	Q15562
B	—	protein	210	—	Q15562

Ligands and binding sites

QSJ · (3R,4R)-1-{3-[(E)-2-(4-chlorophenyl)ethenyl]-4-methoxy-5-methylphenyl}-3,4-dihydroxypyrrolidin-2-one · ligand · 2 copies · chains A, B
GOL · Glycerol · additive · chains A
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6UYB · Crystal structure of TEAD2 bound to Compound 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q15562 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-4 (Q15562) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15562
Elsewhere: RCSB PDB 6UYB · PDBe 6UYB · UniProt Q15562

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