MolNFT v1 · #166690 · protein

SWI/SNF body module

6UXV · Transcription regulatory protein SNF2: “SWI/SNF body module”. Electron microscopy, 20 pockets (best druggability 0.90). MolNFT v1 #166690 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6UXV
Type: protein
Length: 2,193 residues
Chains: 15
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription regulatory protein SNF2; SWI/SNF chromatin-remodeling complex subunit SWI1…
EC: 3.6.4.-
UniProt: P22082, P09547, P18480, P32591, P53628, P18888
Pockets: 20 · best druggability 0.90

Structure

electron microscopy · 14 distinct chains · 53% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription regulatory protein SNF2 (EC 3.6.4.-)	protein	140	56% helix, 0% strand	P22082
B	SWI/SNF chromatin-remodeling complex subunit SWI1	protein	482	54% helix, 1% strand	P09547
C	SWI/SNF chromatin-remodeling complex subunit SNF5	protein	245	27% helix, 13% strand	P18480
D	SWI/SNF complex subunit SWI3	protein	159	42% helix, 1% strand	P32591
E	SWI/SNF complex subunit SWI3	protein	139	37% helix, 3% strand	P32591
F	SWI/SNF complex subunit SWI3	protein	221	72% helix, 0% strand	P32591
G	SWI/SNF complex subunit SWI3	protein	197	67% helix, 0% strand	P32591
H	Transcription regulatory protein SNF12	protein	257	62% helix, 3% strand	P53628
I	Transcription regulatory protein SNF6	protein	109	51% helix, 0% strand	P18888
J	Unknown protein	protein	67	81% helix, 0% strand	—
K	Unknown protein	protein	28	46% helix, 0% strand	—
L, O	Unknown protein	protein	18	67% helix, 0% strand	—
M	SWI/SNF global transcription activator complex subunit SWP82	protein	83	48% helix, 0% strand	—
N	Unknown protein	protein	30	0% helix, 3% strand	—

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1154	0.90	0.92	158	empty
2	508	0.84	0.91	94	empty
3	438	0.83	0.91	82	empty
4	855	0.83	0.86	126	empty
5	982	0.83	0.84	130	empty

Interfaces

52 interfaces between chains.

F–H · 2183 Å² buried · 19 hydrogen bonds · protein-protein
B–H · 2146 Å² buried · 19 hydrogen bonds · protein-protein
G–H · 2041 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1947 Å² buried · 16 hydrogen bonds · protein-protein
F–G · 1913 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6UXV · SWI/SNF Body Module · the same entry in another collection · chain O against O, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22082
Every structure of UniProt P09547
Every structure of UniProt P18480
Every structure of UniProt P32591
Every structure of UniProt P53628
Every structure of UniProt P18888
Elsewhere: RCSB PDB 6UXV · PDBe 6UXV · UniProt P22082 · UniProt P09547 · UniProt P18480 · UniProt P32591 · UniProt P53628 · UniProt P18888

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