Research workbench
SWI/SNF body module
Analyse SWI/SNF body module in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6UXV
- Type
- protein
- Length
- 2,193 residues
- Chains
- 15
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription regulatory protein SNF2; SWI/SNF chromatin-remodeling complex subunit SWI1…
- EC
- 3.6.4.-
- UniProt
- P22082, P09547, P18480, P32591, P53628, P18888
- Pockets
- 20 · best druggability 0.90
Structure
electron microscopy · 14 distinct chains · 53% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription regulatory protein SNF2 (EC 3.6.4.-) | protein | 140 | 56% helix, 0% strand | P22082 |
| B | SWI/SNF chromatin-remodeling complex subunit SWI1 | protein | 482 | 54% helix, 1% strand | P09547 |
| C | SWI/SNF chromatin-remodeling complex subunit SNF5 | protein | 245 | 27% helix, 13% strand | P18480 |
| D | SWI/SNF complex subunit SWI3 | protein | 159 | 42% helix, 1% strand | P32591 |
| E | SWI/SNF complex subunit SWI3 | protein | 139 | 37% helix, 3% strand | P32591 |
| F | SWI/SNF complex subunit SWI3 | protein | 221 | 72% helix, 0% strand | P32591 |
| G | SWI/SNF complex subunit SWI3 | protein | 197 | 67% helix, 0% strand | P32591 |
| H | Transcription regulatory protein SNF12 | protein | 257 | 62% helix, 3% strand | P53628 |
| I | Transcription regulatory protein SNF6 | protein | 109 | 51% helix, 0% strand | P18888 |
| J | Unknown protein | protein | 67 | 81% helix, 0% strand | — |
| K | Unknown protein | protein | 28 | 46% helix, 0% strand | — |
| L, O | Unknown protein | protein | 18 | 67% helix, 0% strand | — |
| M | SWI/SNF global transcription activator complex subunit SWP82 | protein | 83 | 48% helix, 0% strand | — |
| N | Unknown protein | protein | 30 | 0% helix, 3% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.90 | 0.92 | 158 | empty |
| 2 | 508 | 0.84 | 0.91 | 94 | empty |
| 3 | 438 | 0.83 | 0.91 | 82 | empty |
| 4 | 855 | 0.83 | 0.86 | 126 | empty |
| 5 | 982 | 0.83 | 0.84 | 130 | empty |
Interfaces
52 interfaces between chains.
- F–H · 2183 Ų buried · 19 hydrogen bonds · protein-protein
- B–H · 2146 Ų buried · 19 hydrogen bonds · protein-protein
- G–H · 2041 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1947 Ų buried · 16 hydrogen bonds · protein-protein
- F–G · 1913 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6UXV · SWI/SNF Body Module · the same entry in another collection · chain O against O, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22082
- Every structure of UniProt P09547
- Every structure of UniProt P18480
- Every structure of UniProt P32591
- Every structure of UniProt P53628
- Every structure of UniProt P18888
- Elsewhere: RCSB PDB 6UXV · PDBe 6UXV · UniProt P22082 · UniProt P09547 · UniProt P18480 · UniProt P32591 · UniProt P53628 · UniProt P18888
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.