MolNFT v1 · #166660 · protein
Carbonic anhydrase II complexed with salicylic acid
6UX1 · Carbonic anhydrase 2: “Carbonic anhydrase II complexed with salicylic acid”. X-ray diffraction, 2 ligands (SAL, ZN), 2 pockets (best druggability 0.58). MolNFT v1 #166660 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6UX1
- Type
- protein
- Length
- 258 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbonic anhydrase 2
- EC
- 4.2.1.1
- UniProt
- P00918
- Ligands
- SAL, ZN
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbonic anhydrase 2 (EC 4.2.1.1) | protein | 258 | 16% helix, 30% strand | P00918 |
Ligands and binding sites
- SAL · 2-hydroxybenzoic acid · ligand · 4 copies · chains A
- ZN · Zinc ion · metal · chains A
- GOL · Glycerol · additive · chains A
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 173 | 0.58 | 0.81 | 26 | GOL, SAL |
| 2 | 52 | 0.28 | 0.74 | 13 | SAL |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00918
- Elsewhere: RCSB PDB 6UX1 · PDBe 6UX1 · UniProt P00918
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