MolNFT v1 · #166461 · protein
Crystal structure of R173A variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and S-malate
6UQN: “Crystal structure of R173A variant of cytosolic fumarate hydratase from leishmania major in a complex with…”. X-ray diffraction, 3 ligands (SF4, LMR, FUM). MolNFT v1 #166461 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6UQN
- Type
- protein
- Length
- 1,066 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- E9AE57
- Ligands
- SF4, LMR, FUM
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 534 | — | E9AE57 |
| B | — | protein | 532 | — | E9AE57 |
Ligands and binding sites
- SF4 · Iron/sulfur cluster · ligand · 2 copies · chains A, B
- LMR · (2S)-2-hydroxybutanedioic acid · ligand · chains A, B
- FUM · Fumaric acid · ligand · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6UQN · Crystal structure of R173A variant of cytosolic fumarate hydratase from Leishmania major… · the same entry in another collection · chain A against A, TM-score 1.00
- E9AE57 · AlphaFold monomer V2.0 prediction for fumarate hydratase 2 (E9AE57) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9AE57
- Elsewhere: RCSB PDB 6UQN · PDBe 6UQN · UniProt E9AE57
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