UniProt E9AE57
fumarate hydratase 2 (E9AE57)
fumarate hydratase 2 (UniProt E9AE57), EC 4.2.1.2: 22 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 87 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- E9AE57
- Protein
- fumarate hydratase 2
- EC
- 4.2.1.2
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 87 · 7 records with a druggable one
Structures
23 records of E9AE57 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5L2R | Crystal structure of fumarate hydratase from Leishmania major | x-ray diffraction | A, B | LMR, SF4 | 12 (best 0.84) |
| 5L2R | Crystal structure of fumarate hydratase from leishmania major | x-ray diffraction | A, B | LMR, SF4 | — |
| 6MSN | Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor… | x-ray diffraction | A, B | SF4, JYD | — |
| 6UNZ | Crystal structure of cytosolic fumarate hydratase from Leishmania major | x-ray diffraction | A, B, C, D, E, F, G, H | SF4 | 20 (best 0.86) |
| 6UNZ | Crystal structure of cytosolic fumarate hydratase from leishmania major | x-ray diffraction | A, B, C, D, E, F, G, H | SF4 | — |
| 6UO0 | Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with S-malate | x-ray diffraction | A, B | SF4, LMR | 12 (best 0.84) |
| 6UO0 | Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with S-malate | x-ray diffraction | A, B | SF4, LMR | — |
| 6UOI | Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate | x-ray diffraction | A, B | F3S, FE | — |
| 6UOJ | Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with succinate | x-ray diffraction | A, B | SF4 | — |
| 6UP9 | Crystal structure of T467A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4 | — |
| 6UPM | Crystal structure of T467A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | — |
| 6UPO | Crystal structure of H334A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | — |
| 6UQ8 | Crystal structure of R421A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | — |
| 6UQ9 | Crystal structure of R421A variant of cytosolic fumarate hydratase from Leishmania major in a… | x-ray diffraction | A, B | LMR, SF4 | 10 (best 0.84) |
| 6UQ9 | Crystal structure of R421A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | LMR, SF4 | — |
| 6UQB | Crystal structure of R471A variant of cytosolic fumarate hydratase from Leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | 12 (best 0.83) |
| 6UQB | Crystal structure of R471A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | — |
| 6UQL | Crystal structure of R471A variant of cytosolic fumarate hydratase from Leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | 11 (best 0.84) |
| 6UQL | Crystal structure of R471A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | — |
| 6UQM | Crystal structure of R173A variant of cytosolic fumarate hydratase from Leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | 10 (best 0.83) |
| 6UQM | Crystal structure of R173A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4, LMR | — |
| 6UQN | Crystal structure of R173A variant of cytosolic fumarate hydratase from leishmania major in a… | x-ray diffraction | A, B | SF4, LMR, FUM | — |
| E9AE57 | AlphaFold monomer V2.0 prediction for fumarate hydratase 2 (E9AE57) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6UQ9 chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.19 Å
- 6UQ9 chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.19 Å
- 6UQ8 chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.19 Å
- 6UP9 chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.19 Å
- 6UQB chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.20 Å
- 6UQB chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.20 Å
- 6UQL chain A against the predicted model E9AE57: TM-score 1.00, RMSD 0.20 Å
- 6UQL chain A against the predicted model E9AE57: TM-score 1.00, RMSD 0.20 Å
- 6MSN chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.20 Å
- 6UOI chain B against the predicted model E9AE57: TM-score 1.00, RMSD 0.20 Å
Elsewhere
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