MolNFT v1 · #166054 · protein + RNA
Crystal structure of human zinc finger antiviral protein bound to RNA
6UEJ · Zinc finger ccch-type antiviral protein 1: “Crystal structure of human zinc finger antiviral protein bound to RNA”. X-ray diffraction, 2 ligands (SPM, ZN), 1 pocket (best druggability 0.53). MolNFT v1 #166054 on GenesisL1: 3D…
- PDB
- 6UEJ
- Type
- protein + RNA
- Length
- 215 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc finger ccch-type antiviral protein 1; RNA (5'-R(P*UP*CP*G)-3')
- UniProt
- Q7Z2W4
- Ligands
- SPM, ZN
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Zinc finger ccch-type antiviral protein 1 | protein | 212 | 42% helix, 7% strand | Q7Z2W4 |
| B | RNA (5'-R(P*UP*CP*G)-3') | rna | 3 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 210 | 0.53 | 0.77 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 478 Ų buried · 12 hydrogen bonds · protein-nucleic
Compared structures
- 6UEJ · Crystal structure of human zinc finger antiviral protein bound to RNA · the same entry in another collection · chain A against A, TM-score 1.00
- Q7Z2W4 · AlphaFold monomer V2.0 prediction for zinc finger ccch-type antiviral protein 1 (Q7Z2W4) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z2W4
- Elsewhere: RCSB PDB 6UEJ · PDBe 6UEJ · UniProt Q7Z2W4
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