MolNFT v1 · #165589 · protein
Discovery of lysine-targeted EIF4E inhibitors through covalent docking
6U06: “Discovery of lysine-targeted EIF4E inhibitors through covalent docking”. X-ray diffraction, 1 ligand (EI8). MolNFT v1 #165589 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6U06
- Type
- protein
- Length
- 728 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P63073
- Ligands
- EI8
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 182 | — | P63073 |
| C | — | protein | 182 | — | P63073 |
| D | — | protein | 182 | — | P63073 |
Ligands and binding sites
- EI8 · 3-{[(4-cyanophenyl)methyl](1-oxo-1,2-dihydroisoquinolin-7-yl)sulfamoyl}benzene-1-sulfonyl fluoride · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6U06 · Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking · the same entry in another collection · chain A against A, TM-score 1.00
- P63073 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P63073) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63073
- Elsewhere: RCSB PDB 6U06 · PDBe 6U06 · UniProt P63073
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