MolNFT v1 · #165543 · protein

Structure of KU80 von willebrand domain S229A mutant complexed with aplf and xlf ku binding motif

6TYT · X-ray repair cross-complementing protein 5: “Structure of KU80 von willebrand domain S229A mutant complexed with aplf and xlf ku binding motif”. X-ray diffraction, 1 pocket (best druggability 0.48). MolNFT v1 #165543 on GenesisL1…

PDB: 6TYT
Type: protein
Length: 223 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: X-ray repair cross-complementing protein 5; Ala-lys-gly-leu-phe-met…
EC: 3.6.4.-
UniProt: A0A1L8EVE5
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 3 distinct chains · 43% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	X-ray repair cross-complementing protein 5 (EC 3.6.4.-)	protein	206	43% helix, 21% strand	A0A1L8EVE5
B	Ala-lys-gly-leu-phe-met	protein	6	50% helix, 0% strand	—
C	Arg-lys-arg-ile-leu-pro-thr-TRP-met-leu-ala	protein	11	36% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	120	0.48	0.80	29	empty

Interfaces

2 interfaces between chains.

A–C · 635 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 423 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6TYT · Structure of Ku80 von Willebrand domain S229A mutant complexed with APLF and XLF Ku… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1L8EVE5
Elsewhere: RCSB PDB 6TYT · PDBe 6TYT · UniProt A0A1L8EVE5

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