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Structure of KU80 von willebrand domain S229A mutant complexed with aplf and xlf ku binding motif

Analyse Structure of KU80 von willebrand domain S229A mutant complexed with aplf and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6TYT
Type: protein
Length: 223 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: X-ray repair cross-complementing protein 5; Ala-lys-gly-leu-phe-met…
EC: 3.6.4.-
UniProt: A0A1L8EVE5
Pockets: 1 · best druggability 0.48

Structure

x-ray diffraction · 3 distinct chains · 43% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	X-ray repair cross-complementing protein 5 (EC 3.6.4.-)	protein	206	43% helix, 21% strand	A0A1L8EVE5
B	Ala-lys-gly-leu-phe-met	protein	6	50% helix, 0% strand	—
C	Arg-lys-arg-ile-leu-pro-thr-TRP-met-leu-ala	protein	11	36% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	120	0.48	0.80	29	empty

Interfaces

2 interfaces between chains.

A–C · 635 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 423 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

6TYT · Structure of Ku80 von Willebrand domain S229A mutant complexed with APLF and XLF Ku… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1L8EVE5
Elsewhere: RCSB PDB 6TYT · PDBe 6TYT · UniProt A0A1L8EVE5

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