Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with xtp, dampnpp and mn

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• DZ4 · 2'-deoxy-5'-O-[(R)-hydroxy{[(r)-hydroxy(phosphonooxy) phosphoryl]amino}phosphoryl]adenosine · ligand · 4 copies · chains A, B
• CZF · [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · ligand · 2 copies · chains A, B
• MN · Manganese (II) ion · metal · 6 copies · chains A, B
• FE · Fe (III) ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6TXF · Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9Y3Z3
• Elsewhere: RCSB PDB 6TXF · PDBe 6TXF · UniProt Q9Y3Z3