MolNFT v1 · #165404 · protein

The ROR1 pseudokinase domain bound to ponatinib

6TU9: “The ROR1 pseudokinase domain bound to ponatinib”. X-ray diffraction, 1 ligand (0LI). MolNFT v1 #165404 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6TU9
Type: protein
Length: 526 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q01973
Ligands: 0LI

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	267	—	Q01973
B	—	protein	259	—	Q01973

Ligands and binding sites

0LI · 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl) phenyl}benzamide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6TU9 · The ROR1 Pseudokinase Domain Bound To Ponatinib · the same entry in another collection · chain A against A, TM-score 1.00
Q01973 · AlphaFold monomer V2.0 prediction for inactive tyrosine-protein kinase transmembrane… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q01973
Elsewhere: RCSB PDB 6TU9 · PDBe 6TU9 · UniProt Q01973

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.