Crystal structure of the human oxytocin receptor

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 8% strand (DSSP).

Ligands and binding sites

• NU2 · (3~{R},6~{R})-6-[(2~{S})-butan-2-yl]-3-(2,3-dihydro-1~{H}-inden-2-yl)-1-[(1~{R})-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxidanylidene-ethyl]piperazine-2,5-dione · ligand · chains A
• CLR · Cholesterol · ligand · chains A
• PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide, 1 modified (disulfide, alkylation).

Compared structures

• 6TPK · Crystal structure of the human oxytocin receptor · the same entry in another collection · chain A against A, TM-score 1.00
• P30559 · AlphaFold monomer V2.0 prediction for oxytocin receptor (P30559) · a predicted model of the same protein · chain A against A, TM-score 0.56

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P30559
• Elsewhere: RCSB PDB 6TPK · PDBe 6TPK · UniProt P30559