MolNFT v1 · #165109 · protein
Cryo-EM structure of typeii tau filaments extracted from the brains of individuals with corticobasal degeneration
6TJX · Microtubule-associated protein tau: “Cryo-EM structure of typeii tau filaments extracted from the brains of individuals with corticobasal…”. Electron microscopy, 10 pockets (best druggability 0.55). MolNFT v1 #165109 on GenesisL1…
- PDB
- 6TJX
- Type
- protein
- Length
- 642 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 10 · best druggability 0.55
Structure
electron microscopy · 1 distinct chain · 0% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Microtubule-associated protein tau | protein | 107 | 0% helix, 43% strand | P10636 |
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.55 | 0.79 | 34 | empty |
| 2 | 205 | 0.54 | 0.78 | 35 | empty |
| 3 | 96 | 0.39 | 0.77 | 16 | empty |
| 4 | 132 | 0.39 | 0.74 | 19 | empty |
| 5 | 123 | 0.38 | 0.74 | 18 | empty |
Interfaces
11 interfaces between chains.
- A–E · 4482 Ų buried · 126 hydrogen bonds · protein-protein
- A–C · 4478 Ų buried · 123 hydrogen bonds · protein-protein
- B–F · 4473 Ų buried · 122 hydrogen bonds · protein-protein
- B–D · 4471 Ų buried · 127 hydrogen bonds · protein-protein
- E–F · 130 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6TJX · Cryo-EM structure of TypeII tau filaments extracted from the brains of individuals with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 6TJX · PDBe 6TJX · UniProt P10636
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