MolNFT v1 · #165086 · protein

T. gondii myosin a trimeric complex with ELC1

6TJ5 · Calmodulin, putative: “T. gondii myosin a trimeric complex with ELC1”. X-ray diffraction, 2 ligands (CA, CL), 1 pocket (best druggability 0.39). MolNFT v1 #165086 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6TJ5
Type: protein
Length: 312 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calmodulin, putative; Myosin light chain TGMLC1; Myosin-a
UniProt: A0A0F7UZ05, Q95UJ7, O00934
Ligands: CA, CL
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 3 distinct chains · 63% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calmodulin, putative	protein	131	60% helix, 8% strand	A0A0F7UZ05
B	Myosin light chain TGMLC1	protein	137	59% helix, 9% strand	Q95UJ7
C	Myosin-a	protein	44	86% helix, 0% strand	O00934

Ligands and binding sites

CA · Calcium ion · metal · chains A
CL · Chloride ion · ion · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	109	0.39	0.75	17	empty

Interfaces

3 interfaces between chains.

A–C · 1359 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 1318 Å² buried · 24 hydrogen bonds · protein-protein
A–B · 339 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6TJ5 · T. gondii myosin A trimeric complex with ELC1 · the same entry in another collection · chain A against A, TM-score 1.00
O00934 · AlphaFold monomer V2.0 prediction for myosin-a (O00934) · a predicted model of the same protein · chain C against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0F7UZ05
Every structure of UniProt Q95UJ7
Every structure of UniProt O00934
Elsewhere: RCSB PDB 6TJ5 · PDBe 6TJ5 · UniProt A0A0F7UZ05 · UniProt Q95UJ7 · UniProt O00934

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