MolNFT v1 · #165053 · protein
Crystal structure of the SVS_A2 protein (A224I mutant) from ancestral sequence reconstruction at 2.6 a resolution
6THU · SVS_AS10 variant: “Crystal structure of the SVS_A2 protein (A224I mutant) from ancestral sequence reconstruction at 2.6 a…”. X-ray diffraction, 7 pockets (best druggability 0.85). MolNFT v1 #165053 on GenesisL1: 3D structure…
- PDB
- 6THU
- Type
- protein
- Length
- 652 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SVS_AS10 variant
- EC
- 4.2.3.158
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SVS_AS10 variant (EC 4.2.3.158) | protein | 328 | 66% helix, 1% strand | — |
| B | SVS_AS10 variant (EC 4.2.3.158) | protein | 324 | 67% helix, 1% strand | — |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.85 | 0.97 | 59 | empty |
| 2 | 589 | 0.73 | 0.80 | 51 | empty |
| 3 | 506 | 0.68 | 0.79 | 48 | empty |
| 4 | 94 | 0.61 | 0.88 | 19 | empty |
| 5 | 84 | 0.61 | 0.88 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1958 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 6THU · Crystal structure of the SVS_A2 protein (A224I mutant) from ancestral sequence… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6THU · PDBe 6THU
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