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Crystal structure of the SVS_A2 protein (A224I mutant) from ancestral sequence reconstruction at 2.6 a resolution

Analyse Crystal structure of the SVS_A2 protein (A224I mutant) from ancestral sequence… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6THU
Type: protein
Length: 652 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SVS_AS10 variant
EC: 4.2.3.158
Pockets: 7 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 66% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SVS_AS10 variant (EC 4.2.3.158)	protein	328	66% helix, 1% strand	—
B	SVS_AS10 variant (EC 4.2.3.158)	protein	324	67% helix, 1% strand	—

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	248	0.85	0.97	59	empty
2	589	0.73	0.80	51	empty
3	506	0.68	0.79	48	empty
4	94	0.61	0.88	19	empty
5	84	0.61	0.88	17	empty

Interfaces

1 interface between chains.

A–B · 1958 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

6THU · Crystal structure of the SVS_A2 protein (A224I mutant) from ancestral sequence… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6THU · PDBe 6THU

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